The Oregon Health & Science University will receive a $2 billion gift from Nike co-founder Phil Knight and his wife, Penny, to support the eponymous Knight Cancer Institute, OHSU announced last week.

It is the largest single donation ever made to a U.S. university-affiliated health center and is intended to promote the integration of cancer diagnostics, treatment and patient care.

The gift will allow the cancer institute to become self-governed within OHSU. It will have its own board of directors under the leadership of Brian Druker, a leukemia researcher who has worked closely with the Knights and who helped develop a drug that vastly improved the life span of patients with chronic myeloid leukemia.

“This gift is an unprecedented investment in the millions of lives burdened with cancer, especially patients and families here in Oregon,” said OHSU president Shereef Elnahal. “It is also a signal of trust in the superlative work that our clinicians, researchers and teammates at the Knight Cancer Institute do every day. Dr. Druker’s vision around a multidisciplinary system of care—focused squarely on making the patient’s experience seamless from the moment they receive a diagnosis—will now become reality. And thanks to the extraordinary generosity of Mr. and Mrs. Knight, Oregon will be the place to do it.” 

The Knights have been key benefactors of the cancer institute. In 2013 they vowed to donate $500 million if the university could match the funds within two years—which it did, thanks to $200 million in bonds from the Oregon Legislature, $100 million from Columbia Sportswear chair Gert Boyle and assorted donations from some 10,000 individuals from all 50 states and 15 countries.